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The significance of ACE2 in the CV system is in negative regulation of the RAAS, whose activation is associated with the development of CV comorbidities such as hypertension due to increased Ang II concentration, Ang II-induced vasoconstriction, sodium retention, induction of oxidative stress (OS), and induction of inflammation and fibrosis development (75, 76)

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10.1016/j.jad.2023.10.153 64

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Generally, SePs perform their activities within cells, acting as enzymes such as deiodinases and thioredoxin, and also as antioxidants including glutathione peroxidase (GPx), which is regarded as the first animal SePs to be discovered [10]