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Oral forms (capsules, sprays, or drops) are easier to administer

Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed for injection in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

Bottcher, J

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RNAi Cells in 6-well or in 96-well plates in media lacking antibiotics were transfected for 48 h with siRNA pools (siGENOME, Dharmacon RNAi Technologies) directed against murine Mgst2 mRNA (NM_174995.2), human Nox4 (NM_016931.1) or human Chop mRNA (NM_001195053.1), using DharmaFECT 1 reagent (Dharmacon) according to the manufacturers protocol

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