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Clin EEG Neurosci 2011

10.3389/fphar.2020.00567 19 CasajsV.DemkuraP.CivelloP.Gmez LobatoM.MartnezG

The distinction becomes particularly relevant when considering vitro approaches: genetic modification of cells outside the body followed by infusion constitutes gene therapy-mediated cell therapy, such as CAR-T cells, whereas the ASGCT definition classifies this under gene therapy when the genetic alteration is the primary therapeutic mechanism