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Hu et al (141) revealed that AS-IV administration can negatively regulate the expression of the mesenchymal marker vimentin and myofibroblast marker -SMA in db/db mice and HK-2 cells treated with HG

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For context on how these results compare with single-agonist options, semaglutide (Wegovy) achieved 14.9% mean weight loss at 68 weeks in the STEP 1 trial, and retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed up to 24.2% weight loss in Phase 2