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Radiotherapy resistant HIF1 KO NSCLC cells further induce ser/gly synthesis pathway following irradiation, a response non-existent in HIF2 KO cells The observations of a distinct metabolic reprogramming and redox defense mechanism of NCI-H1299 NSCLC cells upon loss of HIF1 and HIF2 might imply divergent mechanisms for their survival in response to oxygen-dependent treatments such as radiotherapy

Mitochondrial CYP27B1 is the only enzyme (requires Mg ++ ) that hydroxylates carbon number one in cholecalciferol, activating 25(OH)D3 (Bikle, 2014

Organic selenium ameliorates staphylococcus aureus-induced mastitis in rats by inhibiting the activation of NF-B and MAPK signaling pathways

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The five on the left are considered "terminal branches"

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