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Jackson JG, Lozano G

Betanzos-Lara, S

HDL and cholesterol handling in the brain

10.1038/s41418-017-0053-8 48

The consequence of hemolysis is particularly evident in hemolytic anemia, where fragility of RBCs is mainly due to redox dysbalance or hemoglobinopathies, for example, sickle cell disease (SCD) (see the section RBC Dysfunction and Anemia for more details), and observed in transfusion of older blood (71)

One of the most prominent approaches within the field is the use of patient-specific iPSCs, which exhibit susceptibility to stressors causing cell death [77], abnormalities in mitochondrial dynamics and function [78] and aberrant neuronal morphology in long-term culture [79]