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Cocaine neurotoxicity and neurological damage stem from several mechanisms, including mitochondrial dysfunction (Poon et al., 2007), neuroinflammation (Moran et al., 2005), and autophagy ( 3.1 Vascular effects of cocaine Cocaine impairs vascular function by causing vasoconstriction, reducing cerebral blood flow, and decreasing tissue oxygenation

10.1007/s10545-014-9707-6 204

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This suggests a potential role in conditions characterized by neurotransmitter dysregulation

Action potentials were evoked by a 1-s depolarizing current injection with a maximum of 200 pA in a ramp mode