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FIGURE 1 Exogenous ROS Environmental triggers, such as exposure to cigarette smoke, UV radiation, heavy metal ions, ozone, allergens, drugs or toxins, pollutants, pesticides, or insecticides, may all contribute to the increase of ROS production in cells (Mahajan et al., 2018

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Trends Cell Biol 30(9):720735 Horton ER, Humphries JD, James J, Jones MC, Askari JA, Humphries MJ (2016) The integrin adhesome network at a glance

While long-term treatment with the HDAC inhibitor vorinostat is well tolerated (54), it remains to be determined whether treatment restricted to a critical window of development would produce self-sustaining neural changes and confer beneficial outcomes