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Before elective orthopaedic surgery, it is recommended to discontinue GLP-1 medications as they can delay gastric emptying and increase aspiration risk during anesthesia

This is consistent with previous findings that the redox state of PDI-family members does not change in response to BSO-mediated glutathione depletion [19]

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Its down to a number of key factors, specifically metabolic rate, weight, height, and (perhaps most important) your reason for trying IV glutathione therapy