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Description

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3.3.1 Background Anxiety disorders represent a group of persistent neuropsychiatric conditions affecting approximately 4.05% of the global population, with prevalence rising by over 55% since 1990 (Javaid et al., 2023)

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The histidine residues provide a tertiary structural interaction with the two domains of PrP and copper, that is also protective in function due to involvement of the conserved central region of the protein (Roseman et al., 2020)