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While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

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These inhibitors block FIN56- or erastin-induced GPX4 degradation to prevent ferroptosis (107,108)

Methods: PBC patients followed in a tertiary hepatology Italian centre with available quantitative AMA-M2 values were included in a cross-sectional analysis

Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2121739119

Hence, we reasoned that Cys uptake may counteract ferroptosis not only through the well-established CysGSHGPX4 axis but also by enabling biosynthesis of S 0 species