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Ovarian primordial follicular cells cannot regenerate, and aberrant death of these cells by chemotherapeutics leads to follicular dysfunction and oocyte atresia, which appears as POI 54

Recent research highlights that inhibition of its rate-limiting enzyme, AR, may substantially mitigate vascular dysfunction and related complications in DM [19, 147]

The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia

doi: 10.1203/00006450-199912000-00007 65