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Despite the potential for multifaceted applications, our understanding of fungal GDHs has many gaps, as highlighted in this review

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However, ADH is considerably more sensitive to small changes in osmolality than changes in blood volume: a 1% decrease of plasma osmolality stimulates ADH secretion, whereas a 10% decrease in blood volume is necessary to clearly increase ADH levels ( Guyton and Hall 2006 )

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