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As of April 2026, all new OROS lyophilized product batches are tested by independent ISO/IEC 17025-accredited laboratories in the United States

By assigning metabolites to the signals shown in the loading plot (Figs 4B and S5B) and quantifying the variation observed for each metabolite among the different classes, we found that overall, vB12 treatment induced significant metabolic changes in Tbx1 +/ mice only (Figs 4A, S5A, and S6, Table S1, Group 3)

Together, these data suggest that fatty acid synthesis and mitochondrial activity are impaired in the Tbx1 +/ brain

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Because they are naturally occurring sequences in the human body, they are generally well-tolerated with minimal documented toxicity