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Consideration of variability of these data allows for extrapolation of a range of in vivo equivalent doses across individuals rather than a single value, which more accurately reflects the distribution of population responses that occur from exposure to a chemical (Wetmore et al

Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer

Figure 2 Numerous studies have highlighted the significance of oxidative stress and reduced GSH levels as major risk factors for neurodegenerative lesions in the central nervous system (CNS) across various neurological diseases (Dringen, 2000)

Figure 1 6.2 Mitochondria-associated membranes and training-induced calcium handling An emerging mechanism distinct from acute exercise involves exercise training-induced remodeling of mitochondria-associated membranes (MAM)tethering domains between the sarcoplasmic reticulum (SR) and mitochondria that regulate calcium flux and apoptotic signaling

Graph neural networks for single-cell omics data: a review of approaches and applications

The PK parameters assessed were the area under the curve (AUC) and peak plasma concentration (C max ), which were quantitatively assessed based on a predefined criterion of two-fold range (0.52.0) of the predicted/observed ratio