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Thus, infection-induced mitochondrial dysfunction and immune activation are reciprocally reinforcing processes that create a vicious cycle of oxidative stress, metabolic reprogramming, and immunopathology

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Saleh, L

Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial

doi: 10.1037/neu0000373 254

This knowledge aids in a more comprehensive understanding of protein inhibitors, conformational activators, cofactors, and enzyme catalytic or active sites at a molecular level, thus enabling the design of superior drugs and enhancing therapeutic efficacy