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Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons

Safety profiles remain based on short-term animal studies rather than lifelong human observation

Titration context: study schedules include eligibility rules and monitoring plans

In some embodiments, the otoprotectant is a compound of Formula (VI) having the structure of Formula (VIa): In some embodiments, the otoprotectant is a compound of Formula (VII): wherein: X is a single bond, double bond, CH 2 , or O

The act of administering an unapproved drug to a human, including self-administration, is prohibited under the Federal Food, Drug, and Cosmetic Act

"NAD+ depletion in brain injury." Translational Neuroscience