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Fu AL, Dong ZH, Sun MJ (2006)

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Phosphorylation of IRF3 by TBK1 dimerizes and translocates IRF3 to the nucleus, inducing the expression of the type I interferon (IFN) gene, interferon-stimulated genes (ISGs), and several other inflammatory mediators, pro-apoptotic genes, and chemokines, which in turn are involved in various pathophysiological processes (141, 145, 146) ( Figure 2 )

Sirtuins include seven NAD + dependent deacetylases associated with post-translational modification of tumor suppressors and transcription factors 9

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More significant metabolic changes were found after 8 weeks than 4 weeks post baseline