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To gain insight into the pathological role of increased GSSSG in the aqueous humor of patients with DR, we next investigated the effect of various glutathione polysulfides (GS(S) n SG) on the survival of retinal cells (specifically, an immortalized line of RGC-5 cells) under conditions of high oxidative stress in vitro

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Taken together, both the proteomic and transcriptomic studies identified many known facets of VitC action in cancer cell killing, including apoptotic, redox and metabolic mechanisms, but also revealed less defined roles of ascorbic acid, such as the regulation of cytoskeleton remodeling and the inhibition of translation (proteomics) as well as DNA replication and repair (transcriptomics)