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In the last years, several preclinical studies and clinical trials have been effectuated using different GSK-3 inhibitors, actually with few encouraging results

Ronchi JA, Francisco A, Passos LA, Figueira TR, and Castilho RF

Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease

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Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F

Conversely, when transsulfuration is stressed, methylation capacity may also be affected