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However, the introduction of -lactamase inhibitors, such as clavulanic acid, has led to combination therapies that remain very effective 1,5,6

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E2 has been found to decrease cardiac output, heart rate, and arterial pressure during CIH exposure by activating ER, which in turn inhibits the activation of the cardiac branch of the sympathetic nervous system and enhances nitric oxide-mediated vasodilatory responses (3)

Western blotting analyses were repeated three times with similar trends and quantified using ImageJ (46)