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For example, many lipolytic proteins such as PLIN1 (13, 130), PNPLA2 (131, 132) and G0S2 (133) are stabilized by condition that promote LD biogenesis, such as oleic acid supplementation, where association with the phospholipid monolayer is thought to mask motifs that signal degradation

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The molecular mechanisms underlying brain stimulation-dependent neuronal excitability and synaptic plasticity have been well elucidated with extensive preclinical animal models

as well as the metabolic disruption detected in the cerebrospinal fluid of SCA3 patients [140,141,142,143,144,145,146,147]

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