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Key virulence factors include internalin-mediated host cell adhesion and invasion, flagella-driven motility, the positive regulatory factor A (PrfA)-regulated transcriptional control of major virulence genes, the listeriolysin O-induced disruption of phagosomal membranes, the phospholipase-mediated evasion of host defense mechanisms, actin polymerization-dependent intracellular and intercellular spread, sigma factor-driven stress responses, biofilm formation and the development of resistance to antimicrobial agents

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Four days after the experiment, it was reported by the researchers that the murine models presented with TB-500 showed an apparent 41% increment in the re-epithelialization process (i.e., formation of new epithelial cells to resurface the wound)

Mater Sci Eng C Mater Biol Appl 130:112450

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Using the metabolic network reconstruction of L