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Activated by both mTORC1 and mTORC2, SGK-1 has been considered to be a negative regulator of autophagy [50, 51]

Larger, randomized controlled trials (RCTs) with longer follow-up periods are necessary to evaluate the efficacy and safety of topical glutathione more robustly

10.1038/nature15521 15 Casgevy and Lyfgenia (2024)

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392 These findings suggest that both the proinflammatory cGASSTINGIFN axis and the anti-inflammatory cytokine IL-10 play crucial roles in mTOR-mediated mitochondrial inflammation and highlight mTOR inhibition as a potential therapeutic strategy for treating inflammatory diseases