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Yao DL, Liu X, Hudson LD, Webster HD: Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis

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Therefore, the manufacture of MNs for wounds requires mechanical strengths to better fit microneedles drug delivery properties (Figures 2CF)

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While this reaction may prevent over-reduction of PSI, it introduces the risk of oxidative damage to stromal proteins and nucleic acids if H 2 O 2 accumulates beyond the capacity of scavenging enzymes like ascorbate peroxidase (APX) or catalase (CAT)