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The mechanisms of other multidrug transporters, including P-glycoprotein (P-gp, ABCB1), ABCG2, and MRP1 have been well-studied

the Tm at pH 4 is 5.5C lower than the Tm at pH 7

Discussion Drug resistance is not a new issue, but remains the greatest difficulty for effective treatment of patients with cancer worldwide

Tumor-derived lactate suppresses cytotoxic T cell activity through multiple mechanisms: inhibiting T cell proliferation, reducing cytokine production, and promoting regulatory T cell (Treg) expansion

Arch Toxicol (2020) 94:144360

All the identified putative GST proteins were nomenclature as prefix Sl for Solanum lycopersicum followed class identifier (e.g., SlGSTU , SlGSTF , SlGSTT , SlGSTZ , SlGSTL , SlTCHQD , SlDHAR , SlEF1B , SlMGST and SlGHR represents tau, phi, theta, zeta, lambda, TCHQD, DHAR, EF1B, mPEGS-2 and GHR class, respectively) and a progressive number for each gene (e.g., SlGSTU 1) according to the previously suggested system [28, 29]