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Increased intra-abdominal pressure also increases intrathoracic pressure, which is rapidly transmitted up through the venous system, thereby further increasing intracranial pressure (Malbrain and Wilmer, 2007

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Circ Res 80:4551 Zalba G, Jos GS, Moreno MU, Fortuo MA, Fortuo A, Beaumont FJ, Dez J (2001) Oxidative Stress in Arterial Hypertension: Role of NAD(P)H Oxidase

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Moreover, studies reported that 4-HNE plays a role in inflammatory responses and apoptosis of osteoarthritic chondrocytes