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More recently, it has been shown that, still via the ANS, a peripheral inflammation can induce the appearance in the insular cortex, of inflammation-specific engrams associated with specific ensemble of neurons

These inflammatory proximal tubular cells can significantly downregulate GSH metabolic genes, making cells more prone to ferroptosis, resulting in repair failure after kidney injury, ultimately promoting kidney fibrosis and the progression of AKI to CKD (209)

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doi: 10.1038/s41419-024-06558-0

The process at Focal Point consists of 3 treatments at the frequency of initial, 6 months, 12 months

Hal Scofield is a physician-scientist at the Oklahoma Medical Research Foundation, and he also serves as associate chief of staff for research at the Oklahoma City VA Medical Center