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A lack of ATP can result in incomplete degradation, generating potentially toxic intermediate species that can seed additional fibril aggregation [163, 171]

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Because no mutation was found in specimens from her parents, hereditary evidence for epimutation was not obtained

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In line with these data, here we provide, to the best of our knowledge, the first description of autophagy in melanocytes and fibroblasts from non-lesional vitiligo skin and we show that this process is part of a broader metabolic program and may act as a compensatory/protective response towards the intrinsic metabolic vulnerability

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