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Tricyclic antidepressants (TCAs) exert their primary therapeutic effect by blocking the presynaptic reuptake of norepinephrine and serotonin, thereby increasing synaptic concentrations and enhancing neurotransmission in these systems ( Selective serotonin reuptake inhibitors (SSRIs) are currently the most prescribed antidepressants due to their favorable efficacy and safety profiles

Second, existing FDA-approved epigenetic drugs may be repurposed for IS treatment: DNMT inhibitors (e.g., 5-azacytidine and decitabine) could restore GPX4 and SLC7A11 expression(Yan et al

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Food challenges may also be done, most often when skin tests and/or history is inconclusive