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2007 doi: 10.1152/ajpcell.00115.2007

These pathogens possess choline TMA-lyase activity, enabling the conversion of dietary choline into trimethylamine (TMA), a precursor to TMAO, and exhibit invasive capabilities that allow them to enter and persist within vascular tissues

Moreover, SL improved diet-induced NASH with liver fibrosis by disturbing the role of the inflammatory cytokine and suppressing the activation of HSCs (Kim et al., 2012)

Also, brain oxidative stress biomarkers, including brain malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD), brain-derived neurotrophic factor (BDNF) as well as heme oxygenase-1 (HO-1) were measured