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Kharat SS, Ding X, Swaminathan D, Suresh A, Singh M, Sengodan SK, et al

These cells are also "immune privileged", meaning they can work without triggering immune rejection, making them especially effective in aiding recovery

Epub 2008/01/01

In addition, the small leucine-rich repeat proteoglycan of bone extracellular matrix tissue biglycan, which is correlated with an aggressive phenotype of osteosarcoma, supported tumor growth and induced resistance to chemotherapy drug doxorubicin by forming a complex with IGF-1R leading to activation of the IGF-1R signaling pathway in human osteosarcoma cell line MG63 (37)