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In summary, exerkines, as beneficial products, have the potential to serve as targets for the development of clinical drugs or nutrients

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Generally, compounds of the Formula I, may be prepared by standard solution phase or solid-phase synthesis from commercially available inputs by procedures well established in the art

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Evidence for the sepiapterin synthesis pathway in humans comes from a recent study of rare patients with sepiapterin reductase deficiency, in which sepiapterin levels were elevated in cerebrospinal fluid, which suggests endogenous production of sepiapterin [69]