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10.1002/dta.2214 55

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Similar to the effect observed in cells lacking FLCN , TFEB is dephosphorylated and accumulates in the nucleus of TSC2 -deficient cells in spite of Rheb and mTORC1 hyperactivity [100,101], reinforcing the notion that TFEB regulation is completely insensitive to mTORC1 activation by Rheb