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Proceedings of the National Academy of Sciences of the United States of America 99 (24): 1555415559

First, mechanistic studies should integrate single-cell transcriptomics and spatial metabolomics to map cell-type-specific ferroptosis pathways in hippocampal and cortical neurons and microglia, with particular focus on the link between NCOA4-mediated ferritinophagy and A clearance, thereby building a dynamic model connecting iron dysregulation, proteotoxic stress, and cell death

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Furthermore, Mn can induce apoptosis

Species are organized taxonomically (fish, birds, non-human mammals, and humans)

They also secrete profibrotic cytokines such as TGF- and IL-6, which promote further fibroblast differentiation and recruit additional inflammatory and fibrogenic cells, thereby amplifying a positive feedback loop that sustains fibrosis (121123)