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In recent years, the incidence and mortality rate of AKI has been on the rise

FEMS Microbiol Rev 45:fuab033 Gonzalez-Magana A, Altuna J, Queralt-Martin M, Largo E, Velazquez C, Montanchez I, Bernal P, Alcaraz A, Albesa-Jove D (2022) The P

ludwiggi protects against DSS-induced colitis by enhancing the choline/7nAChR-mediated dendritic cell immune tolerance, leading to increased Foxp3 + Treg differentiation ( + dendritic cells from Enterobacter ludwiggi -treated mice exhibited higher expression of tolerogenic markers Tgfb1, Tgfb2, Aldh1a2 , and Pdl1 , and co-culture with nave CD4 + T cells enhances Treg conversion ( Enterobacter ludwiggi exhibited reduced colitis severity and expanded Treg populations in the mesenteric lymph nodes and spleen, highlighting cholines role in shaping gut-immune interactions

Also, numerous pharmacokinetic studies have been carried out on AGN and its constituents, such as decursin and its isomer

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