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The specific response depends on the nature and severity of the side effect, but general principles guide appropriate action

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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of target genes involved in glutathione synthesis, iron sequestration, and detoxification of lipid peroxides ( In the cancer context, aberrant activation of the Nrf2 is frequently observed and contributes to tumor progression by counteracting lipid peroxidation and ferroptosis

Those cases, in which antioxidant therapy has been shown to have a positive effect, will also be discussed

At room temperature: Gel