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These biochemical relationships demonstrate that folate availability and MTHFR activity define the upper limit for DNA and histone methylation, providing a mechanistic bridge to the epigenetic phenotypes described in autoimmune diseases (95-97,99)

Immunity (2017) 46(4):67589

Simona, F., Zhang, H

von Loeffelholz C, Docke S, Lock JF, Lieske S, Horn P, Kriebel J, Wahl S, Singmann P, de Las Heras Gala T, Grallert H, Raschzok N, Sauer IM, Heller R, Jahreis G, Claus RA, Bauer M, Stockmann M, Birkenfeld AL, Pfeiffer AFH (2017) Increased lipogenesis in spite of upregulated hepatic 5AMP-activated protein kinase in human non-alcoholic fatty liver

Little), U01NS098969 (R.M.R.) and U01NS117836 (R.M.R.)

The depletion of VSMCs leads to structural defects in the arterial wall, promoting the formation of IAs [84, 85]