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A randomized controlled trial published in PMC demonstrates that older humans (71.1 years) exhibited significantly lower glutathione levels, impaired mitochondrial fatty-acid oxidation, reduced gait speed and physical function, and higher oxidative stress compared to young controls (25.5 years)

There are some reports showing that angiogenesis inhibitors could not support therapeutic effect in previously treated metastatic breast cancer [187]

This dosage results in a dose-dependent increase in plasma concentrations of UroA and its glucuronide and sulfate conjugates, supporting its physiological activity in target tissues, particularly muscles and their mitochondria (Reference Andreux, Blanco-Bose and Ryu14)

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