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Statements Author contributions SD: concept of review, collected different data, wrote the manuscript, AD: collected all the COVID-19 data both global and India, prepared the figures and table, PK and KR: wrote many parts of the second phase of the manuscript, collected information about it and prepared the references and edited the manuscript

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Thyroid hormones regulate numerous metabolic processes: Basal metabolic rate and energy expenditure Protein synthesis and cellular metabolism Cardiovascular function including heart rate and contractility Growth and development in multiple organ systems Levothyroxine is typically taken once daily on an empty stomach, ideally 30-60 minutes before breakfast

JNK is activated during oxidative stress and plays a central role in APAP-induced hepatotoxicity 60

While its assumed TB-500 might behave similarly to fulllength T4, there is no evidence for this

Excess ROS in the ovary deteriorates oocyte competence, induces GCs apoptosis, disrupts GCsoocyte communication, alters cytoskeletal and spindle assembly dynamics, and accelerates ovarian aging through mitochondrial dysfunction, telomere shortening, inflammation, and apoptosis (Prasad et al., 2016