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Arteriolar tone establishes the blood flow into an organ, and capillary resistance and rheology factors determine RBC heterogeneity within the capillary bed (Bateman et al., 2003)

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After that, divalent metal transporter 1 (DMT1) transports Fe2 + into the labile iron pool in the cytoplasm (Katsarou and Pantopoulos, 2020)

Interestingly, this was also reflected in the protein abundance level of antioxidative enzymes

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In ATM-wt tumors (n=5), high-dose tBHQ (100 M) induced a 571 fold upregulation of NRF2 target genes (Figure 1B)