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In addition to exhibiting selectivity and saturability, active transport requires the expenditure of energy and may be blocked by inhibitors of cellular metabolism

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Strik MC, de Koning PJ, Kleijmeer MJ, Bladergroen BA, Wolbink AM, Griffith JM, et al

Moreover, the hypoxia factor HIF-1 induces upregulation of mitochondrial Lon and promotes IL-6 secretion through indirect effects on STAT3 72

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