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Non-responders are rare (probably under 5%)

The concomitant activation of crypt-associated signalling pathways mobilises neighbouring epithelial cells to temporarily restore the barrier, and, in the long term, allows the proliferation and differentiation of the ISCs to restore the damaged epithelium [37, 38, 82]

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The PI3K/AKT pathway is an important regulator of cell cycle progression

Springer, New York, NY, pp 167180 Floh L, Toppo S, Orian L (2022) The glutathione peroxidase family: discoveries and mechanism

2013 paper (PMID: 23055539) has an Expression of Concern issued by the journal in 2021, and the Benoist et al