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Side effects tend to be mild

Arch Biochem Biophys 82 , 707 (1959)

doi: 10.3390/biomedicines10020289 187 MarteauPSeksikPJianR

Reasons for CAB+LEN: NNRTI mutations, integrase mutations, high viral loads, continued viremia on CAB/RPV alone 24% were cis/trans female, 42% Black/Af Am, 36% Latinx 94% achieved viral suppression at 8 weeks (47% suppressed at baseline) 71% were on q8wk CAB dosing, though the authors state initially using q4wk dosing may be prudent pending further study for patients with adherence challenges

Differential Diagnosis The differential for new-onset hyperglycemia or a suspected diabetes diagnosis is broad

The mechanism of oxidative cell death Excessive ROS can directly damage organelles, including the plasma membrane, ultimately leading to cell death [71]