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The tolerogenic mechanism is elegant: by presenting histone epitopes in a context that promotes regulatory rather than effector T cell responses, these peptides essentially re-educate the immune system to tolerate its own nuclear components

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Melatonin neutralizes reactive oxygen species (ROS) and free radicals by donating electrons to them

doi: 10.3390/pharmaceutics14102014 [DOI] [PMC free article] [PubMed] [Google Scholar] 73.Bhargava A, Osusky M, Hancock RE, Forward BS, Kay WW, Misra S