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This review discusses the potential of CD19 CAR-T cells in ARDs, highlighting clinical achievements and addressing key considerations such as optimal target cell populations, CAR construct design, acceptable toxicities, and the potential for lasting immune reset, crucial for the safe and effective adoption of CAR-T cell therapy in autoimmune treatments

Specifically, BHB binds to and engages hydroxycarboxylic acid receptor 2 (HCAR2, also known as GPR1O9A) and free fatty acid receptor 3 (FFAR3, or GPR41) [43]

doi: 10.3390/ijms24129835 46 LiYHuangZPanSFengYHeHChengSet al

Rationale and study design of a randomized, placebo-controlled, double-blind phase 2b trial to evaluate efficacy, safety, and tolerability of an oral glutaminyl cyclase inhibitor varoglutamstat (PQ912) in study participants with MCI and mild AD-VIVIAD