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Regarding papaverine, a direct-acting vasodilator, when injected intraperitoneally in noise-exposed Wistar rats significantly decreases the apoptotic death of hair cells resulting in significantly smaller threshold shifts when compared to noise-exposed untreated animals (Kum et al., 2018)

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Neuronal input triggers Ca2+ influx through AMPA receptors and voltagegated Ca2+ channels in oligodendrocytes