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To overcome therapeutic resistance, targeting metabolic pathways, combination therapies, and the development of drugs aimed at the tumor microenvironment offer new hope

Critical Appraisal of Individual Studies The included systematic review (SR) 18 was critically appraised by one reviewer using AMSTAR II, 19 the non-randomized study (NRSs) 20 was assessed using the ROBINS-I Tool, 21 and guidelines 12 , 22 24 were assessed with the AGREE II instrument

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5.3.4.2 Liver fibrosis and cirrhosis In a liver fibrosis model induced by a high-fat diet combined with carbon tetrachloride, bile duct ligation, ethanol, and other factors, betaine exerted its effects through the aforementioned antioxidant and anti-inflammatory mechanisms and directly targeted the antifibrosis pathway

They are usually noticed as dark patches or small dark spots on the lips