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The detailed description of the divergent DDIs mechanism of the 16 drugs across the three databases is summarized in Supplementary Table SB

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Lin Z, Simeone DM, Anderson MA, Brand RE, Xie X, Shedden KA, et al

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While your dimer simulations capture the interface beautifully, expanding to atomistic dynamics with active, multi-transducer bound states seems like the natural next step to decode how specific TM orientations shape downstream G-protein coupling and -arrestin regulation

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