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Moreover, oral NR was found to boost NAD + levels not only via the NMRK pathway but also through its degradation first into NAM by the enzyme CD157 (also known as BST1 which is present in the small intestine) and then into NA by the gut flora [205]

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Elevated NNMT is linked to: Reduced NAD+ availability Slower mitochondrial function Increased fat storage efficiency Higher risk for insulin resistance By reducing NNMT activity, 5-Amino-1MQ allows the body to maintain higher NAD+ levels, which can support better mitochondrial performance, improved fat oxidation, and more balanced energy metabolism

3.van Walraven C, Austin P, Naylor CD